Three Vectors of Immune Responsiveness
This model summarizes work done in late 90’and early 2000’s looking at the effect of immunizations against cancer. This was made possible by the discovery of genes that encode for antigens recognized by T cells. For example, the vaccine against gp100, which is expressed by melanoma and that is given through a series of immunizations, makes you develop T cells that recognize the vaccine. In fact, following immunizations these T cells increase in numbers reaching the point that we have patients that have 50% of the circulating CD8 cells recognizing the antigen. But the most important thing is that there is absolutely no correlation with response. So, why do you have all these cells and nothing happens?